![]() In the group of patients who were node pretreatment node-positive, 28 of 50 (56%) were downstaged to N0 following chemotherapy. Overall, 30 of 85 patients' tumors (35.3%) showed pCR following neoadjuvant chemotherapy. Relationship Between Hormone Receptor and HER2 Results Before Neoadjuvant Chemotherapy Nonetheless, FISH was performed in this case and showed gene amplification with HER2/CEP17 ratio of 2.4. The classic lobular carcinoma reportedly yielded 2+ staining at an outside hospital, but repeated staining in our laboratory showed 1+ staining. Of the 3 lobular carcinomas in this series, the 2 with pleomorphic morphology showed 3+ staining. Per American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) guidelines this tumor was scored as 2+ and reflexed to FISH, which showed gene amplification ( HER2/CEP17: 2.2 HER2 signals per cell: 5.2) ( Figure 1, D). One tumor with micropapillary features showed a basolateral HER2 staining pattern, 19 characterized by relatively weak membranous staining that is noncircumferential and more pronounced in the basolateral aspect of the gland not facing the stroma ( Figure 1, C). Grade 3 tumors showed significantly more frequent HER2 3+ staining than grade 2 tumors (76.2% versus 46.5%, P =. 03), as was the mean number of HER2 signals per cell (15.03 versus 7.06, P =. ![]() The mean HER2 FISH ratio was significantly greater in IHC 3+ tumors than in those with 0 to 2+ staining (5.93 versus 3.27, P =. 14 For cases in which FISH was performed, the number of HER2 signals per cell and HER2/CEP17 ratio were recorded from the original FISH reports. 17 HER2 IHC stains were scored: 0, 1+, 2+, or 3+. 16 H-scores for HRs were grouped into 3 categories: low positive (1–100), moderate positive (101–200), and high positive (201–300). The H-score, which produces a value ranging from 0 (no staining) to 300 (diffuse strong staining), represents the sum of percentage of tumor nuclei staining at each intensity level multiplied by the staining intensity (0 = staining, 1 = weak staining, 2 = moderate staining, and 3 = strong staining). ER and PR were assessed by using a semiquantitative approach to generate an H-score for each case. The ER, PR, and HER2 IHC-stained slides were reviewed for all cases. Histologic type and any notable morphologic features such as mucinous, micropapillary, apocrine, or lobular differentiation were recorded. Each tumor was graded according to the Nottingham System. Hematoxylin-eosin slides from core biopsy and excision samples were reviewed by 3 pathologists. ![]()
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Black Ink Cartridge Compatible 364XL BK CB316EE Blacks are clear and highly pigmented with the 364XL BK CB316EE remanufactured high capacity. ![]() ![]() ![]() I shall indemnify and hold harmless the Company and all other Releasees against any and all losses, damages, liabilities, deficiencies, claims, actions, judgments, settlements, interest, awards, penalties, fines, costs, or expenses of whatever kind, including reasonable attorney fees, fees and the costs of enforcing any right to indemnification under this Agreement, and the cost of pursuing any insurance providers, incurred by/awarded against indemnified party in a final judgment, arising out or resulting from any claim of a third party related to the Activities (including any claim brought by my child, and/or his or her representatives). I forever release and discharge the Company and all other Releasees from liability under such claims. I hereby waive and release any and all claims against the Company, and its officers, directors, employees, agents, affiliates, members, successors, and assigns (collectively, “Releasees”), on account of injury, death, or property damage arising out of or attributable to my and/or my child’s participation in the Activity, whether arising out of the negligence of the Company or any Releasees or otherwise. I acknowledge that running, climbing on furniture, hanging on structures, jumping, throwing, smashing or any other destructive behavior is not permitted at any time at Genius Gems, and is grounds for immediate removal from Genius Gems. I ACKNOWLEDGE THAT I AM VOLUNTARILY SIGNING MY CHILD UP TO PARTICIPATE IN THE ACTIVITIES WITH KNOWLEDGE OF THE POTENTIAL DANGER INVOLVED AND HEREBY AGREE TO ACCEPT AND ASSUME ANY AND ALL RISKS OF INJURY, DEATH, OR PROPERTY DAMAGE, WHETHER CAUSED BY THE NEGLIGENCE OF THE COMPANY OR OTHERWISE. I ACKNOWLEDGE THAT ANY INJURIES THAT I OR MY CHILD MAY SUSTAIN MAY BE COMPOUNDED BY NEGLIGENT EMERGENCY RESPONSE OR RESCUE OPERATIONS OF THE COMPANY. ![]() I AM AWARE AND UNDERSTAND THAT WHILE GENIUS GEMS WILL TAKE REASONABLE PRECAUTIONS TO AVOID AND/OR MINIMIZE THE RISK OF INJURY, CERTAIN ACTIVITIES COULD POTENTIALLY INVOLVE THE RISK OF SERIOUS INJURY AND/OR DEATH AND/OR PROPERTY DAMAGE, INCLUDING THE POTENTIAL FOR SMALL PARTS OR MAGNETS TO CAUSE CHOKING OR OTHER INJURY. I UNDERSTAND THAT GENIUS GEMS IS DESIGNED FOR CHILDREN AGES FOUR AND OLDER WHO ARE CAPABLE OF FOLLOWING STAFF INSTRUCTIONS. As lawful consideration for being permitted by the Company to participate in the Activity, I agree to all the terms and conditions set forth in this agreement (this “Agreement”). They then use paper and markers with their project to make custom spin art.I, and/or a minor for whom I am legal guardian (referred to as “my child”), desire to have my child and/or family participate in classes or other general admission programs (the “Activity”) provided by GENIUS GEMS, LLC, a Delaware limited liability company, with offices located at 215 Millburn Ave, Millburn, NJ 07041 (the “Company”). Guests are guided in wiring a motor circuit with a battery pack and a motor that connects to our specially made, 3D printed parts. Guests are guided in wiring a motor circuit with a battery pack and motorized fan, inserting it into a housing they decorate Spin Art Machine (best for ages 9-12) Guests are guided in choosing and arranging charms, gems, letters, and glitter to decorate their own Glitter Tile, which can be used on any brand of magnetic tile. Depending on availability, there is an option of choosing glow-in-the-dark or color-changing powder to slime for an additional cost. Guests are guided in using our clear base slime, glitter, colorant, and other add-ins to create their own slime. Guests are guided in creating an LED circuit using an LED light and a battery pack, inserting it into a housing they decorate. Guests are guided in creating an LED circuit using an LED light and a battery pack, inserting it into the end of a wand they decorate. The shape is pre-selected by the host family. ![]() Guests are guided in creating an LED circuit using an LED light and a battery pack, inserting it into a laser-cut shape they decorate. Premium Projects LED Shaped Project (best for ages 6-8) ![]() ![]() ![]() Welcome Spring and Your Guests with Porch Enclosure Systems' Innovative New Product STEVENSVILLE, Md. When she found… Read more…Īs Seen in The Star Democrat: Jumpstart the Outdoor Season with Porch Enclosure Systems She had considered enclosing her porch and got a quote from a patio enclosure company but realized she’d lose her screened porch. This customer wanted to enjoy her screened porch with her family into the fall/winter season. Porch Enclosure Interview: Chester, MD: Laura Gourley As temps got cooler, his wife added curtains but they weren’t sufficient to keep out the cold and blocked the sun (good in… Read more… Steve is a builder who added a beautiful screened porch with stone fireplace next to his pool. Maryland Home Builder, Crown Homes, Endorses Porch Enclosure Systems After helping the owner’s supervise a porch build 3 years previous, the owners decided they wanted to host a Thanksgiving dinner there for 22… Read more… Restorations, a construction supervision company, was working on a client’s second home in St. We… Read more…ĭesign/Build Firm, Restorations, Chooses Porch Enclosure Systems "We have a second floor screened porch and we didn’t want to turn it into a three-season room. ![]() Leon is the President of Rommel USA which owns and operates 11 Ace Hardwares, Rommel Engineering & Construction & Rommel Electrical. They want an outdoor space with the beautiful… Read more…Īce Hardware Chain President Recommends PES Waterfront homeowners want the best quality and glasslike clarity. The enclosure is the perfect compliment to this newly built home, extending the seasonal use of the porch and keeping it clean and dry.Īt Porch Enclosure Systems, we use the very best-in-class pressed polished vinyl sheet glass to enclose outdoor spaces at coastal and waterfront properties. I didn’t have to consider wiping anything down,” Gourley says. the PES product is great because I went out and everything was clean. But I love to have the cushions and the comforts of fabric and pillows. “If you want to have a porch where you can hose everything down, great. Now that she has an enclosure in their new home, a cleaner porch year round means less work for her, and more time enjoying the benefits of her outdoor living space. “We’d say, let’s have dinner there tonight, and then I’d have to go out and spend a half hour cleaning before we ate, so it became a space that we didn’t really use.” ![]() “We lived on the water in the woods and we had a screened porch in our last house, but we never used it because it was filthy dirty all the time because of all the pollen,” says homeowner Laura Gourley of Kent Island, Maryland (two photos above). We also love machine washable options so you can easily clean them if needed.Laura Gourley: Chester, MD: Interior view of PES, including door and over door vent panels. Since curtains will be exposed to the elements, it's important to choose a curtain that was made specifically for use outdoors so it can withstand the weather it may be exposed to. Plus, the curtains we love that are on the market now that you can buy to recreate these looks on your own front porch. STRING CURTAINS PATIO DOOR FLY SCREEN ROOM DIVIDER DOOR WINDOW FRINGE CURTAINS 4.49 to 19.99 Sienna Crushed Velvet Curtains PAIR of Eyelet Ring Top Fully. FREE delivery Sat, Sep 9 on 25 of items shipped by Amazon. Not only do curtains add a nice visual element to porches and serve as a way to express your personal design taste, but they can also help add privacy as well as shade from the sun to keep the temperature on your porch cooler during warmer weather.īelow, we're sharing some of our favorite front porches with curtains. NICETOWN 2 Panels Outdoor Curtains for Patio Waterproof, Stainless Steel Grommet Indoor Outdoor Vertical Drapes for Front Porch & Canvas, W55 x L84, Taupe. Whether you have a wraparound porch, a small porch, a screened porch, or an open porch, there is a style of curtain on this list that will fit any style. 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![]() ![]() You’ll be locked into any career series you sign up for but I found the Manufacturer Drives and other invitational events break things up quite nicely. It offers more freedom to choose the exact teams you want to race for in each motorsport series (and more of them in general) and there’s a new “Manufacturer Drives” event list, which allows us to score gigs as regular factory drivers for many of the included carmakers. Power in Your CornerThe massive career mode is similar to the first game, with a few positive tweaks. It doesn’t replace the ability to set your car up manually but it is handy for Cole Trickle-types who need a Harry Hogge to do their car whispering for them. There’s even a built-in race engineer that will suggest tuning changes based on the feedback you give it. Project CARS 2 is a tremendously deep destination for racing diehards but it doesn’t want to outright intimidate people. 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Accustomed to simple textures and barely distinguishable faces, the gamer is shocked to see a monster in a close-up with luxurious detail on every part of its body.Īs with the image, the sound also impacts the opposites. This is done to highlight the scares and entities that attack the player. A lot of attention was paid to the drawing, but it still feels that the characters intentionally need more intricate detail. The most characteristic is the dichotomy of details in the overall imagery. Despite its simple colors, this gives fresh air to art, making it very peculiar compared to other titles. Similarly, the developers chose not to use black lines to draw the boundaries of the elements. The game's palette is quite varied, but a certain predisposition to the combination of opaque colors with dull pastels can be noticed. This had a massive impact on the title's focus, where the already heavy atmosphere would increase significantly in the presence of its multimedia resources. Personal Nightmare was the first to receive these changes so that players could enjoy a 16-bit submission. With the advent of more powerful consoles like the Commodore, Horror Soft saw the possibility of exploiting the audiovisual part of its titles. With a limited inventory and the constant obligation to make the right decisions, the experience is manageable from its very mechanics. Furthermore, the game is based on writing and choosing correctly between various dialogues and solving puzzles. The imposed limit of 4 days creates pressure on the player and traps him in a constant race against the clock. ![]() First of all, there is a day and night real-time system. It also features many components that the user must be aware of if he wants to survive the adventure. In Personal Nightmare, your father is an oddball vicar, and a letter from your mother. The gameplay of the release is quite dynamic. Here is the first in a series of horror adventures from Horror Soft. On the other hand, the protagonist only has four days to achieve this feat. The objective is to eliminate all of them and confront the devil. At the very beginning, the player is given the premise that the devil attacked his neighborhood and began to possess its inhabitants. The game is the direct forerunner of two Elvira-based installments: Elvira: Mistress of the Dark and Elvira II: The Jaws of Cerberus.ĭespite not having a specific plot, the game has a clear focus. The title was released for the Amiga, Atari ST, and MS-DOS. Won't anyone let you in on the terrible secret that haunts your walking moments.Personal Nightmare is a horror game developed and published by Horror soft in 1989. In order to pursue a more interesting career opportunity you left home many years ago and lost contact with your parents. Brought up a vicars son, life was very quiet in this sleepy little village. It's as if you are living through your worst nightmare and unable to wake up. Personal Nightmare - Manual The village of Tynham Cross, nestled in the hills of Woldshire, holds many childhood memories for you.
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